Cardiovascular Disease Continuum

Peripheral artery disease (PAD) is an occlusive of extremities, which used to be diagnosed and treated as isolated the limbs or other parts body. Nowadays, role PAD transcends affected limb; instead, cardiovascular system must observed a whole, with having prognostic role. About 200 million people are by worldwide. The prevalence likely increase steadily in future due global aging population predominantly sedentary lifestyle, along expected universal major risk factors such smoking habit, diabetes mellitus, dyslipidemia hypertension. Patients at higher coronary events comparison healthy control subjects. severity correlates development complications disease. In patients, percutaneous intervention more demanding, associated comorbidities, complex lesions, poorer procedural success compared PAD-free patients. For year now, use antiplatelet therapy acetylsalicylic acid combination low (vascular) dose direct oral anticoagulant has been recommended for lower limb protection future, we expect better understanding atherosclerotic disease, stronger modulation systemic inflammation, discovery new therapies. meantime, it necessary identify aggressively treat classic – blood pressure, glycemia lipids therapy. goal protect preserve continuum. negative consequences COVID- 19 on treatment CVD will estimated following years.